Telomere shortening and telomere position effect in mild ring 17 syndrome

Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances.

While global chromatin conformation studies are emerging, very little is known about the chromatin conformation of human telomeres. Most studies have focused on the role of telomeres as a tumor suppressor mechanism. Here we describe how telomere length regulates gene expression long before telomeres become short enough to produce a DNA damage response (senescence). We directly mapped the intera...

Telomere shortening, atherosclerosis, and metabolic syndrome.

This mechanism resembles inflammatory reactions to exogenous factors and the wound healing process (2). Dysfunction of vascular endothelial cells is thought to induce a cascade of pathologic reactions of cell groups mediated by the expression of adhesion molecules, resulting in infiltration of mononuclear cells, foam cell formation, promotion of thrombus formation, and disturbed relaxation of b...

Telomere Shortening Mechanisms

Rapid telomere shortening in children.

Telomere shortening may reflect the total number of divisions experienced by a somatic cell and is associated with replicative senescence. We found that the average rate of telomere shortening in peripheral blood mononuclear cells (PBMCs) obtained longitudinally from nine different infants during the first 3 years of life (270 bp per year) is more than fourfold higher than in adults and does no...

Accelerated Telomere Shortening in Acromegaly; IGF-I Induces Telomere Shortening and Cellular Senescence

OBJECTIVE Patients with acromegaly exhibit reduced life expectancy and increased prevalence of age-related diseases, such as diabetes, hypertension, and cardiovascular disease. However, the underlying mechanism has not been fully elucidated. Telomere shortening is reportedly associated with reduced life expectancy and increased prevalence of these age-related diseases. METHODS We measured tel...